Genetics
Familial Susceptibility For Degenerative Brain Disease Caused By Genetic Mutation
Mutation of a gene that helps proteins migrate in and out of the cell's genetic command center - the nucleus - puts some families at higher risk for the degenerative brain disease acute necrotizing encephalopathy (ANE). This is the conclusion of a global study to be published Jan. 9 by the American Journal of Human Genetics, and currently posted online, that was led by a researcher from Cincinnati Children's Hospital Medical Center.
Kategorien: Genetics
Protein Has Pivotal Role In Obesity, Metabolic Syndrome
A protein known to play a role in development and the formation of organs is also an important factor in the control of obesity and diabetes, said researchers from Baylor College of Medicine in a report that appears in the current issue of the journal Cell Metabolism. Drs.
Kategorien: Genetics
Protective Gene Variant Becomes Bad Actor On A High-Fat Diet
New evidence in mice bolsters the notion that a version of a gene earlier shown to protect lean people against weight gain and insulin resistance can have the opposite effect in those who eat a high-fat diet and are heavier, reveals a report in the January 7th issue of the journal Cell Metabolism, a Cell Press publication.
Kategorien: Genetics
For Scientists Who Track Interactions Between Cell Proteins, A Time Of Reckoning Has Arrived
During the past 20 years, researchers have identified thousands of cell protein interactions, with the ultimate goal of inventorying all that occur within cells of various organisms - a comprehensive catalogue known as the interactome. Such information will be critical to understanding the basic mechanics of cellular life, and how malfunctions in these processes contribute to cancer.
Kategorien: Genetics
Dangerous New Method For Bacterial Toxin Transfer Discovered By NYU Scientists
Scientists have discovered a new way for bacteria to transfer toxic genes to unrelated bacterial species, a finding that raises the unsettling possibility that bacterial swapping of toxins and other disease-aiding factors may be more common than previously imagined.
Kategorien: Genetics
Newsweek Opinion Pieces Examines Race-Based Medicine
Jerry Adler, senior editor for Newsweek, examines research into the genetic differences between racial groups in a recent opinion piece for the magazine. According to Adler, the question of "what, if any, are the significant genetic differences between racial groups ... that we use to define 'race'" was "virtually a closed question in academia" for decades.
Kategorien: Genetics
Protein's Essential Role In Repairing Damaged Cells Revealed
University of Michigan researchers have discovered that a key protein in cells plays a critical role in not one, but two processes affecting the development of cancer. "Most proteins involved in responding to DNA damage that can cause cancer either help detect the damage and warn the rest of the cell, or help repair the damage," says David O. Ferguson, M.D., Ph.D., the study's lead author.
Kategorien: Genetics
Evolution Caught In The Act: Biologist Finds Plant Polymerases IV And V Are Really Variants Of Polymerase II
It's a little like finding out that Superman is actually Clark Kent. A team of biologists at Washington University in St. Louis has discovered that two vital cellular components, nuclear RNA Polymerases IV and V (Pol IV and V), found only in plants, are actually specialized forms of RNA Polymerase II, an essential enzyme of all eukaryotic organisms, including humans. "We've caught evolution in the act," said Craig Pikaard, Ph.D.
Kategorien: Genetics
'Scrawny' Gene Keeps Stem Cells Healthy
Stem cells are the body's primal cells, retaining the youthful ability to develop into more specialized types of cells over many cycles of cell division. How do they do it? Scientists at the Carnegie Institution have identified a gene, named scrawny, that appears to be a key factor in keeping a variety of stem cells in their undifferentiated state. Understanding how stem cells maintain their potency has implications both for our knowledge of basic biology and also for medical applications.
Kategorien: Genetics
Yale Researchers Create An Epic Genetic Atlas Of Rice
Yale researchers have published a cellular atlas of genetic activity in rice, documenting with unprecedented detail how and when genes are turned off and on within cells of a living organism. The staggering amount of data collected during the five-year project, published online in the journal Nature Genetics, chronicles the molecular differences and similarities among 40 cell types essential to the life cycle of one of the world's most important crops.
Kategorien: Genetics
Cequent To Present First Proof Of Activity Of An Oral RNAi Drug In Non-Human Primates At February Keystone Conference
Cequent Pharmaceuticals, a pioneer in the development of novel products to deliver RNAi-based treatments to prevent and treat human disease, announced that the company has recently completed a successful toxicology study of its candidate CEQ501, an orally administered tkRNAi therapeutic targeting the primary oncogene (beta-catenin, CTNNB1) in FAP (familial adenomatous polyposis). FAP is an inherited gastrointestinal disease that causes hundreds of polyps to form in the colon.
Kategorien: Genetics
New Tumor Suppressor For Lung Cancer Identified By Cell Biologists
Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer. The study, led by Jorge Moscat, PhD, appears in the January 2009 issue of Molecular and Cellular Biology.
Kategorien: Genetics
Discovery Of Uncultured Bacteria In Amniotic Fluids Of Women Who Experience Preterm Births
Researchers from Case Western Reserve University and Yale University have made a significant advancement in understanding the cause behind why some pregnant women suffer from inflammations in the inner womb without any signs of an infection.
Kategorien: Genetics
Genetic Variation May Lead To Early Cardiovascular Disease
Researchers from Duke University Medical Center have identified a variation in a particular gene that increases susceptibility to early coronary artery disease. For years, scientists have known that the devastating, early-onset form of the disease was inherited, but they knew little about the gene(s) responsible until now. The results are published January 2 in the open-access journal PLoS Genetics.
Kategorien: Genetics
CSH Protocols Features Methods For Studying DNA Repair And Protein Modification
This month's issue of Cold Spring Harbor Protocols (http://www.cshprotocols.org/TOCs/toc1_09.dtl) features two articles detailing experimental methods for the analysis of molecular processes involved in DNA repair and post-translational modification of proteins. Homologous recombination is an important mechanism for the repair of damaged chromosomes.
Kategorien: Genetics
Improved Understanding Of Complex Mechanisms That Regulate DNA Damage Control And Replication In The Cell Cycle
Scientists at Burnham Institute for Medical Research (Burnham) have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating replication following DNA repair. Since Ddk is often deregulated in human cancers, this new understanding of its role in DNA damage control could help shape new cancer therapies. The research was published in the
Kategorien: Genetics
Possible Mechanism Of Muscle Denervation In Emery-Dreifuss Muscular Dystrophy
Mutations in the nuclear intermediate filament lamin A/C (LMNA) gene are associated with Emery-Dreifuss muscular dystrophy, but cause the disease by unknown mechanisms. Méjat et al. show that one mechanism involves the disruption of neuromuscular junctions. The study appeared online on Monday, January 5, 2009 (http://www.jcb.org) and in the January 12, 2009 print issue of the Journal of Cell Biology.
Kategorien: Genetics
New Genetic Markers For Ulcerative Colitis Identified, Researchers Report In Nature Genetics
An international team led by University of Pittsburgh School of Medicine researchers has identified genetic markers associated with risk for ulcerative colitis. The findings, which appear today as an advance online publication of the journal Nature Genetics
Kategorien: Genetics
New Insight Into Aggressive Childhood Cancer
A new study reveals critical molecular mechanisms associated with the development and progression of human neuroblastoma, the most common cancer in young children. The research, published by Cell Press in the January 6th issue of the journal Cancer Cell, may lead to development of future strategies for treatment of this aggressive and unpredictable cancer.
Kategorien: Genetics
In Breast Cancers With Poor Prognosis Gene Plays Dual Role
A new study reveals that the metadherin gene (MTDH) plays a role in both cancer metastasis and resistance to chemotherapy. The research, published by Cell Press in the January 6th issue of the journal Cancer Cell, identifies MTDH as a promising therapeutic target for high risk breast cancers.
Kategorien: Genetics
- Coming of Age in the Era of AIDS
- Forcing pregnant women to take HIV tests
- Delusions in HIV and cancer treatment
- Competing theories of AIDS: Is HIV irrelevant?
- Causes of death among children younger than 4
- Syphilis causes "HIV" viral load spike, and T-cell decrease
- Finding your own road
- Parasite epidemic of the 1970s renamed AIDS in 1981
- Bob Barr Recants DOMA Very Publically, A Couple of Months After Two Relevant Votes
- To Minimize Harm Legalize Marijuana: New Scientist - NewsGrabs 4 January 2009
- Aids: An Iatrogenic Depopulation Strategy?
- US: Stevia sweetener approved - NewsGrabs 28 December 2008
- "The gay movement should always, always be about expanding freedom for everyone, even bigots"
- Open source health research - NewsGrabs 21 December 2008
- Rick Warren, Gay Heartbreaker
- Ain't That a Shame
- Could Microwave Technology End Human Race? - NewsGrabs 14 December 2008
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- Liquidia Technologies to collaborate with Abbott on siRNA therapeutics
- Control of blood vessels a possible weapon against obesity
- Mountaineers measure lowest human blood oxygen levels on record
- UK survival for children's bone cancer lowest in Western Europe
- Levitating nanomechanics shows potential to improve medicine
- Prevalence of Drug-Resistant HIV-1 in Rural Areas of Hubei Province in the People's Republic of China.
- Envelope Coreceptor Tropism, Drug Resistance, and Viral Evolution Among Subtype C HIV-1-Infected Individuals Receiving Nonsuppressive Antiretroviral Therapy.
- Early Control of HIV-1 Infection in Long-Term Nonprogressors Followed Since Diagnosis in the ANRS SEROCO/HEMOCO Cohort.
- Health-Related Quality of Life in a Randomized Trial of Antiretroviral Therapy for Advanced HIV Disease.
- Successful Integration of Tuberculosis and HIV Treatment in Rural South Africa: The Sizonq'oba Study.
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