Holistics

GS is a member of the GK Blog who lives in New Delhi India. His mother's stage four breast cancer was considered terminal. We worked together to change his mother's current treatment protocol to one that I believed would be more effective. GS asked lots of questions. We spoke on the phone many times. He wasn't going to do anything just because I said so. At present, his mother has no cancer in her body. It is gone except for some lymph nodes lodged between her liver and pancreas. We don't know if these lymph nodes are lymphomas, or inflammed lymphoid organs. The following is his story.

PAST HISTORY
My mother was diagnosed with an advanced form of Breast cancer in feb 2005. She was immediately
operated upon her left breast and the connecting lymphnodes were removed. This was
followed by Chemo therapy of just Dosetaxol, the CT scan detectable signs of cancer
were gone in 3 months, the chemo continued, severe side effects befell upon her.

Just 8 months later her BP one day went up to 200 by 140 and with a severe pain
in her head she developed double vision due to her right eye. Then suddenly this double
vision started to turn into a right sided paralysis, parkinson’s like shaking and severe lack
of motor control in just 4 days with inability to speak or swallow.
Upon mri investigations they found her dural meningis to be swollen along with her
cerebellum at the base of her brain. The Wbc and protein in her cerebro spinal fluid were
elevated.

This could mean she had a cancer speading to her brain or / and autoimmune disease
called paraneoplastic syndrome or meningitis. None of these could be established.... as
we couldnt take her CSF again and again, they take the CSF 4 times to rule out cancer mets or
Paraneoplastic syndrome. Upon Further CT Scans they found a pea sized tumour at the lymph site where surgery was done and a lymphatic spread was found on her liver as well, the stomach and one
adrenal gland appeared bulky, there was also a metastatic lymph node under the liver.
She was put through radiation of the cerebellum before chemo with dexamethasone.

While the radiations were on we switched our oncologist upon being told that radiation should not be
done before chemo, the doc also said the breast surgery shouldnt have been done till after the chemo
and the lymph nodes not removed. The new oncologist administered gemcite and carboplatin over 18 doses and everything cleared up over CT scan prognosis.
We needed to get a Chemoport installed in her chest before the chemo which is still flushed
every 30 days with 5-10 ml of Heparin.The liver had a scar with a fatty deposit from the cancer assault. The doctor said the disease had been well controlled.
The double vision was now almost gone but persisted due to shaking of the eye.
She still has a lot of physical weakness, lack of motor control and inability to walk
and speak. Her physical symptoms are more like a severe parkinson’s case.
My mom still had severe lack of appetite, mild indigestion, acidity, belching, feels
very cold, weak.

WHAT WE DID TO PREVENT CHEMO AGAIN AND AGAIN.

By this time we realized that we would be there torturing my mom with chemos every year once a
year then every couple of months till the chemo took her life.
This is what we are did immediately after to fight the disease:

On 1st of Jan 2007 she started taking 15 grams of MSM which has made here veins which
hadnt revived in over 2 years start appearing in just 1 month. She took atleast 8 grams of
msm a day religiously and was unable to pass off a decent stool without it, so she enjoyed it, sadly
these were the few pleasure she had left besides her rosary which she had chanted all her life and still
chants for several hours till today.

She took a 100 mg Vitamin B, 1 gram of C, 1 gram of coral calcium, 400 mg of CoQ10
daily We’ve only stopped Coq10 a week before the ultrasound of the liver mentioned
below.VShe took 1 softgel of flax oil which also contains fish oil to go with the q10 this is going
on without the q10 right now. Extra 1mg of folic and B12 each also taken without fail to combat pernicious anaemia.1/3rd to 1 teaspoon of Curcumin with piperine this is being off and on, she says it helped
her feel warmer, q10 made her feel cold.
She took Some kind of a multivitamin complex for seniors iron-free daily we used many brands.
The latest one was Vitacost version 2 one a day formula it contains 200 mcg niacin bound chromium.
After that for about 4 months she been took a herbal mixture ( almost 1 cup ) containing one
branch Aloevera juice, Wheatgrass juice, 12 leaves neem, 1 gram
Withania Somnifera root, 6 inches of Tinospora cordifolia stem, and 7 leaves of Dark holy basil. This formula was given to us by a herbalist he asked us to add periwinkle flowers as well but we didn’t because we feared we might need vinchristine or vinbalstine chemo in future. It turns out a couple of these herbs
She did a month of oral laetrile protocol and for 5 months she got gastric side effects couldn’t take it
anymore.

During this time she started using the Dr. clark Zapper twice a day, and 4.5 grams of IP6
blended with 1 gram inositol (cellforte )
She also took 1 mg melatonin and 1.5 mg alprazolam to sleep. 4 mg
EMSET – (Zofran, Ondansetron) for nausea daily
She needed 2.5 mg of amlovas (amlodipine) for hypertension – her
Blood pressure was then 5-12 point below the upper and lower limit – we stopped amlovas.
Her blood pressure became 120 - 122 / 80 without the pill.

Liver Ultrasound:
Due to her very poor appetite we got a liver ultrasound done.
The findings / comments were as follows:
Liver - measures 13.2 cm craniocaudally in mid clavicular line (normal is < / = 15.5) –
the radiologist verbally commented its slightly small during the scan. No evidence of any
focal parenchymal lesions noted. IHBR is normal, Portal and hepatic veins are mormal is
course and caliber. Portal vein measure 8mm (normal is < /= 13mm) she didn’t comment
anything here. Mild coarse Echotexture.

Gallblader- well distentedwith clear lumen and normal wall thickness, no calculus seen
CBD – normal in caliber
Spleen – normal in size (7.3 cm) and echotexture. No forcal or diffuse lesion seen
Both kidneys = are normal is size, she position and echotexture. No evidence of any
calculus or hydronephrosis.
There is a small precaval lymphnode posterior to pancreas measuring 1.2 x 1.7 cm
in size - This could definitely be cancerous. We were scared so we found Dr. Martin.
I explained the whole protocol we had done for my mother so far to Dr. Martin and he was kind
enough to push forward his Cytotoxic oxidative stress protocol ahead of schedule for my mom.
I was Extremely grateful to him

This is what we did with the protocol:
The protocol we did lasted for 40 days total so far.
this included (and none of the old protocols):
1 MG SODIUM SELENITE divided
40 - 50 GMS L-GLUTAMINE
10-15 GMS ISOLEUCINE
25000 -50000 IU BETACAROTENE (STARTED ON THE 10TH DAY)
2 POLICOSANOLS IN DIVIDED DOES A DAY
2-3 TEASPOONS OF SWANSONS SDG FLAX LIGNANS (STARTED ON THE 15TH DAY
FOR 8 DAYS)
2000 IU VITAMIN D A DAY FOR 20 DAYS
A CONCOCTION OF 7 LEAVES HOLY BASIL 7 LEAVES NEEM IN SOME WHEATGRASS
JUICE and Wormwood tincture (artimisinin)
ZAPPING WITH THE DON CROFT ZAPPER ORIGINALLY DR. HULDA CLARKS DESIGN
(ELECTRICITY TO KILL PATHOGENS) This is the first time we felt a zapper actually works
10 MG OF MELATONIN STARTED ON THE 30TH DAY
1 HEAPED TEASPOON OF SODIUM SALICYLATE FIRST THING IN THE MORNING IN A
GLASS OF WATER (25 DAYS)
2-2.5 SULINDACS Pills A DAY (40 DAYS)
2 tabs LITHIUM OROTATE HANS NEIPER BRAND A DAY

She took a drop of Lugols iodine everyday in water – I bought book saying this can be a singular
treatment for breast and prostate cancer. Breast Cancer and Iodine" by Dr. David Derry
Read about Dr. Derry on Natural NEWS.com
The vitamin d overload caused hypercalcemia then i started with some K2 did it for week but we
were scared it might clot her chemo port
she comfortably takes 2000 iu of Vitamin D a day now.

This is how Dr. Martins protocol helped.
1. Her appetite came back immediately in a week
2. Her mood started to improve she felt more happy than sad
3. She started to gain weight again
4. Her hair started to grow again
5. The Blood pressure stated to rise again – im waiting for the Pindolol to arrive from the US
6. Her self confidence started to rise again and we started to go out on a wheel chair for
outings (please keep in mind she is clinically 70% + disabled)
7. The speech cleared up tremendously for the first time it was severely slurred.
8. My mom used to get up twice every night to go to urinate to the bathroom.... one of us
carry her on a chair to take her there and put her on the pot. She sleeps soundly till 6 in
the morning and goes just once to urinate now at 6 am.

Immediately after the protocol we went in for a PET scan and decided to see to the original good
oncologist.
The most important Para in the PET scan report read.
'' There is evidence of an FDG avid (SUV Max:11.3) heterogeneously enhancing Necrotic lymph
nodal mass at the porta measuring approx. 2.2 x 1.0 x 2.8 cm (AP x TR x CC)
It is encasing the portal Vein and abutting the head of the pancreas. Fat planes between the head
of the pancreas and liver appear indistinct.
Mildly FDG avid lymph node with heterogeneous peripheral enhancement is also noted in the
aortocaval region measuring 1.2 x 1.4 x 2.3 cm ''

The next day when my dad went to my moms clinical oncologist at XXXX Hospital.
He waited 5 hours before his turn.... We were really glad he met the doctor - You ll read why?
The man is a noble person and probably the busiest oncologist in Asia maybe the world.
He is head oncology of 4 hospitals in India, starts with a smiling and patient face at 7:30 in
the morning sees 250 - 300 patients a day in different parts of Asia and India.
Finishes his day at 8pm and then goes to individual Wards to see his patients.
He some how manages to remember everyones case history by face.
He does this all smilingly on a Wheelchair - and you can tell his old mans smile is true simple
and genuine.

The Dr. was shocked to see my dad? He remembered it had been a long time.
There were 3 other doctors in the room (his assistants - also oncologist)
My dad handed him the PET scan reports and the History.
He said '' Mr. XXXX - you are handing me CLEAN scan reports of a Stage 4 patient
after 20 months'' how has this happened?
''ALL her organs are clean - you are obviously doing something good to your wife and its working
-- You dont know how happy you've made me today ''
----at this 2 other doctors got up from their chairs to see the reports themselves.
The Doctor then said '' Mr. XXXX Please just keep doing what your doing - its working ''
He asked my dad for the biopsy analysis Which read ---- ER PR weakly positive and HER2 1+
---- so the doctor said as far as I go these figures are treated as negative, and then wrote
LETROZOLE tab SUGGESTED (humbly)

Were not off the Hook yet – im scared about the pancreas. Im going to use D- limonene with
sulindac Watercress and Vitalica Gel caps (40 mg SGS) instead of the broccosprouts. Will also use Beta
glucans in the immunotherapy phase --- the Video on YouTube  by Dr. Boncini – that cancer is like a
fungus is really amazing – Beta glucans is a potent macrophage activator and its derived from yeast cell
wall so it might train the immune system to attack cancer--- it cant hurt so this will be besides Dr.
Martins protocol.

Tried the Mebendazole my moms appetite went for a Strike Out the first day. Might go back to the
Half maximal cytotoxic dose with all the other things to get rid of the Nodules. Might even do the
minimal DCA with minimal caffeine and B1 – there is no way we will know if she ever had brain
mets. We would rather take out the cancer slowly if her life is not in danger . By the way the liver
looked good on the pet scan and normal size too.

Thank You Dr. Martin – You had promised youd come true as her Angel of Health and you did.
We still have a lot of work to do. Im going to Try and give you the Study by Dr. Henry Lai about
electricity and cancer. It does no harm, but might kill cancer stem cells passing through the vein.
She has not caught a cold in 20 months.

One more thing I always check the words angiogenesis when I look up a HERB or nutrient on
cancer. If it shuts down angiogenesis its good enough. By the way fat soluble B1 increases angiogenesis to repair nerves I think I read it somewhere. I may be wrong but Im just trying to say be careful...
look up all your stuff based on the cytotoxic and cytoprotective pathways Dr. Martin mentions
just be sure you dont goof up. Dont over do oxidative stress Dr. Martin uses only safe levels of
ROS in his protocols and talk to him based on your patients weight and condition use your own
head.

This is to all of you stage 4 breast cancer patients out there all I want to say is '' There is still hope were hopeful and so we came till here '' If you feel you were helped in anyway by this letter please pray for my mom –she is all I got and my only wealth. Your prayer can be just one line from the heart.

Love
G.S.
Ps. When I was young my mom would give me money to chant my rosaries and pray. I developed faith
in God in my early years thanks to her. She is like a little 5 ft angel to me full of prayers love and
gentleness. Please pray for her - she is all I got.

SUMMARY

GS is a very intelligent man who knows how to listen. When we discussed his previous protocol, he did not take offense when I objected to almost everything he was doing. In my experience, some people become addicted to their current protocol and don't want to change. Invariably, this resistance to change costs them their lives. My biggest problem is convincing people that anti-oxidants promote cancer cell growth. A few days ago a client told me that his oncologist told him to stop juicing. The juiced ingredients could interfere with his treatment. Of course, FRESHLY juiced fruits and vegetables contain lots of anti-oxidants. This didn't occur to me before.

I would like to thank GS for the feedback and kind remarks. If you are reading this essay on the Public Blog, please send this essay out to anyone who has breast cancer. Stage Four breast cancer does not have to be a terminal disease.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Cimetidine, the generic version of the popular anti-ulcer drug Tagamet, is a potentially powerful anti-cancer drug, especially if combined with other compounds.

If you conduct a PubMed search on cimetidine and cancer you will find over 1000 references.

The epidermal growth factor receptor (EGFR) is over expressed on carcinoma cells. These epithelial cells comprise over 80% of all cancers. Blocking the activity of these receptors is the subject of many research projects.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18337605&itool=pubmed_docsum

This study shows that common, inexpensive, non-toxic cimetidine blocks the activation of EGFR. When EGF, epidermal growth factor, binds EGFR it initiates an autophosphorylation reaction which activates the receptor and its tyrosine kinase activity. Cimetidine blocks this response, thereby blocking EGFRs ability to promote cancer cell growth and the inhibition of apoptosis.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17295779&itool=pubmed_docsum

The authors found that cimetidine decreased the level of cyclic AMP in the cancer cells. The lack of cyclic AMP impaired the autophosphorylation of the EGFR and inhibited its activity. This is an observation of monumental significance. Other histamine H2 receptor inhibitors, such as ranitidine and famotidine, do not decrease the level of cyclic AMP in cells.

I have written extensively about the prostaglandin PGE2 and its ability to suppress the immune response in general and its ability to promote angiogenesis and the growth of cancer cells. PGE2 promotes the synthesis of cyclic AMP. I have also written about the role stress hormones, such as norepinephrine and epinephrine, play in inhibiting the immune response and promoting cancer cell growth and development. These hormones also activate cyclic AMP synthesis.

Cimetidine could decrease cyclic AMP levels in cells by blocking membrane adenylate cyclase, the enzyme that actually makes cyclic AMP, or by increasing the activity of cyclic AMP phosphodiesterase, the enzyme that degrades cyclic AMP. To date, no one knows how cimetidine influences cyclic AMP levels in cells.

Cimetidine, probably via decreased cyclic AMP levels, decreases the development of regulatory T cells. These cells, referred to as TREG, suppress immune functioning. These cells are activated by the immune hormones IL-10 and TGF-beta, hormones that cimetidine downregulates. In addition, cimetidine activates the synthesis of IL-12, the major enhancer of cell mediated immunity.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18502198&itool=pubmed_docsum

There are two major forms of TREG immune inhibitor cells. These cells inhibit a vigorous immune response against cancer, leukemia, bacterial and viral infections, such as HIV.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18613849&itool=pubmed_docsum

The IL-10/TGFbeta hormones responsible for the activation of this subset of TREG cells is inhibited by cimetidine due to its ability to reduce cyclic AMP levels in cells.

The second subset, FOXP3 TREG cells, is also activated by cyclic AMP. This implies that cimetidine can inhibit this population of TREG cells as well.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16785520&itool=pubmed_docsum

The implications of this line of research are enormous. Cimetidine, by lowering cyclic AMP levels in cells, can reactivate the immune response against cancer, HIV and other diseases while inhibiting angiogenesis and the growth of cancer cells.

The daily dose is 800 mgs a day, 200 mgs four times a day. And you don't need a prescription.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Mebendazole is a generic, inexpensive prescription medicine used to treat worm infections. This drug is called a spindle poison because it interrupts the formation of microtubules, cellular filaments that separate newly made DNA. Chemo drugs such as Taxol and alkylating agents are also spindle poisons, but they have toxicities that mebendazole does not have.

http://en.wikipedia.org/wiki/Mebendazole

http://www.mayoclinic.com/health/drug-information/DR600879

In the last few years, a number of studies have found that mebendazole is a powerful inducer of apoptosis in a wide variety of cancer cells, both in culture dishes and mouse models.

In the following study, half maximal cytotoxic doses of mebendazole in the range 0.1 to 0.8 microM (VERY low) killed a wide diversity of cancer cells, including lung, breast, ovary, colon and osteosarcomas. These studies were also conducted in mice. Mebendazole also inhibited angiogenesis.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=12231542&itool=pubmed_docsum

Unlike microtubule disruptive drugs such as Taxol and alkylating agents, mebendazole does not harm normal cells.

The following study was published this month. It shows that mebendazole kills two different strains of chemotherapy resistant melanoma cells. One strain contained a mutant p53 protein while the other harbored a normal p53 tumor suppresor protein. Mebandazole kills the cells equally. The half maximal cytotoxic dose was 0.32 microM.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18667591&itool=pubmed_docsum

Cimetidine, the generic version of the anti-ulcer drug Tagamet, promotes the toxicity of mebendazole by inhibiting its degradation in the liver.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=3663452&itool=pubmed_docsum

The average blood concentration of mebendazole after a single clinical dose is 1.67 microM. This value vastly exceeds the concentration of mebendazole needed to kill a host of different cancer cells.

Mebendazole is usually sold as a chewable tablet. When chewed and allowed to remain in the mouth for a short period, the mebendazole can enter the blood through the mucosal membranes of the mouth. Of course, it can also enter the blood via the GI tract. This drug is extremely non-toxic even in doses of 4.5 grams a day.

Microtubule inhibitors are THE target of interest for chemo drugs. In this case, a simple anti-worm drug inhibits microtubule functioning at low non-toxic concentrations. In a culture dish and in mice, mebendazole induces apoptosis in a diversity of cancer cells at extremely low concentrations.

Unfortunately, this drug will NEVER enter clinical trials as a treatment for cancer.  There is no money to be made.

Fortunately, physicians can prescribe this drug for the treatment of cancer without a clinical trial. This blog and the referenced articles contain all the scientific justification that they will need.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

CDC understated number of new HIV infections in US
By MIKE STOBBE, AP Medical Writer 28 minutes ago

The number of Americans infected by the AIDS virus each year is much higher than the government has been estimating, U.S. health officials reported Sunday, acknowledging that their numbers have understated the level of the epidemic.

The country had roughly 56,300 new HIV infections in 2006 — a dramatic increase from the 40,000 annual estimate used for the last dozen years. The new figure is due to a better blood test and new statistical methods, and not a worsening of the epidemic, officials said.

But it likely will refocus U.S. attention from the effect of AIDS overseas to what the disease is doing to this country, said public health researchers and officials.

"This is the biggest news for public health and HIV/AIDS that we've had in a while," said Julie Scofield, executive director of the National Alliance of State and Territorial AIDS Directors.

The revised estimate by the Centers for Disease Control and Prevention and the methodology behind it were to be presented Sunday, the opening day of the international AIDS conference in Mexico City.

Since AIDS first surfaced in 1981, health officials have struggled to estimate how many people are infected each year. It can take a decade or more for an infection to cause symptoms and illness.

One expert likened the new estimate to adding a good speedometer to a car. Scientists had a good general idea of where the epidemic was going; this provides a better understanding of how fast it's moving right now.

"This puts a key part of the dashboard in place," said the expert, David Holtgrave of Johns Hopkins University.

Based on the new calculations, officials believe annual HIV infections have been hovering around 55,000 for several years.

"This is the most reliable estimate we've had since the beginning of the epidemic," said Dr. Julie Gerberding, the CDC's director. She said other countries may adopt the agency's methodology.

According to current estimates, around 1.1 million Americans are living with the AIDS virus. Officials plan to update that number with the new calculations, but don't think it will change dramatically, a CDC spokeswoman said.

The new infection estimate is based on a blood test that for the first time can tell how recently an HIV infection occurred.

Past tests could only detect the presence of HIV, so determining which year an infection took place was guesswork — guesswork upon which the old 40,000 estimate was based.

The new estimate relies on blood tests from 22 states where health officials have been using a new HIV testing method that can distinguish infections that occurred within the last five months from those that were older.

The improved science will allow more real-time monitoring of HIV infections. Now, CDC officials say, the estimate will likely be updated every year.

Yearly estimates allow better recognition of trends in the U.S. epidemic. For example, the new report found that infections are falling among heterosexuals and injection drug users.

Some experts celebrated that finding, saying it's a tribute to prevention efforts, including nearly 200 syringe exchange programs now operating in 36 states despite a federal ban on funding for such projects.

But they also lamented the CDC's finding that infections continue to increase in gay and bisexual men, who accounted for more than half of HIV infections in 2006. Also, more than a third of those with HIV are younger than 30.

Some advocates say that suggests a need for more prevention efforts, particularly targeting younger gay and bisexual men.

For years, AIDS was considered a terrifying death sentence, and since 1981, more than half a million Americans have died. But medicines that became available in the 1990s turned it into a manageable chronic condition for many Americans, and attention shifted to Africa and other parts of the world.

Last week, President Bush signed a $48 billion global AIDS bill to continue a program that he called "the largest commitment by any nation to combat a single disease in human history."

But some advocates complain that CDC's annual spending on HIV prevention in the United States has been held to roughly $700 million since 2001, while costs have risen. (That's about 3 percent of what the federal government spends on AIDS; much of the rest is on medicines, health care and research.)

The new estimate is "evidence of a failure by government and society to do what it takes to control the epidemic," said Julie Davids, executive director of the Community HIV/AIDS Mobilization Project.

Whether more funding comes or not, the revised estimate clearly is a "wake-up call to scale things up," said Dr. Kevin Fenton, who oversees CDC's prevention efforts for HIV/AIDS.

Some said more attention needs to focus on prevention among blacks, who account for nearly half of annual HIV infections, according to the new CDC report.

A recent report by the Black AIDS Institute concluded that if black Americans were their own nation, they would rank 16th in the world in the number of people living with HIV.

"We have been inadequately funding this epidemic all along. We need to step it up," said former U.S. Surgeon General Dr. David Satcher, who is now an administrator at Atlanta's Morehouse School of Medicine.

The new estimate has been anticipated for a long time. The CDC began working on the new methods nearly seven years ago.

Late last year, advocates said they had heard the figure was about 55,000 and pressed the CDC to release it. Agency officials declined, saying they were submitting their research for medical journal review.

"These are extremely complicated statistical methods," and CDC officials wanted the work to be thoroughly reviewed by outside experts, Gerberding said. CDC's findings are being published in the Journal of the American Medical Association.

Until 1992, the number of diagnosed AIDS cases was used to predict how many people were newly infected each year. That method produced an estimate of 40,000 to 80,000. More recently, the CDC focused on infections among men who have sex with men, who account for about half of new HIV diagnoses.

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